ABSTRACT
Background and Objective: Atypical chemokine receptor 1[ACKR1] represents an atypical chemokine receptor that can bind promiscuously to various chemokines. Chemokines play a crucial role to recruit leukocyte subsets migration through the endothelium and into liver against the virus during the progression of hepatitis C virus [HCV] infection. Most HCV positive patients can lead to liver fibrosis. Hyaluronic add [HA], laminin [LN], collagen IV[C-IV] and amino-terminal pro-peptide of Type-Ill pro-collagen [Pill NP]are indices of the extent of liver fibrosis. The aim of this study was to investigate the association between ACKR1 polymorphism and liver fibrosis with these four serum liver markers in HCV positive patients
Methods: From April 2015 to December 2015, a total of 210 patients [109 males and 101 females] with chronic HCV infection at Dalian Infectious Hospital were recruited to participate in this study. ACKR1 genotyping was using TaqMan probes method. HA, LN, C-IV and Pill NP were detected by using diagnostic kits
Results: We compared serum levels of HA, LN, C-IV and Pill NP between FYA/FYA and FYA/FYB patients and the differences were not significant [P=0.905, P=0.298, P=0.880 and P=0.470, respectively]
Conclusions: This study has attempted to elucidate the role of ACKR1 polymorphism in liver fibrosis progression of HCV infection, our results demonstrated that ACKR1 polymorphism is not directly associated with the fibrogenesis in HCV positive patients